Abstract

Malaria is a global health problem that is still a major cause of morbidity and mortality in the tropical and sub-tropical areas of the world. Ficus asperifolia (Moraceae) has been ethno medicinally used as analgesic, anti-tumor, diuretic, abortificient, and antimalarial. The aim of this study was to evaluate the antiplasmodial activity and short term safety profile of methanol leaf extract of Ficus asperifolia (FaMLE). Phytochemical screening was conducted as described by Trease & Evans and oral median lethal dose (LD50) of the extract was estimated using the OECD guidelines. Subchronic toxicity was evaluated by administering1000, 500, and 250 mg/kg graded doses of FaMLE daily for 28 days p.o. This is followed by biochemical and hematological analysis. The antiplasmodial activity was evaluated in mice infected with chloroquine-sensitive plasmodium berghei-berghei using suppressive, prophylactic